MTHFS report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MTHFS at tissue level.

III. Associated gene sets

GO_0015942Biological processformate metabolic process
GO_0046655Biological processfolic acid metabolic process
GO_0046657Biological processfolic acid catabolic process
GO_0006536Biological processglutamate metabolic process
GO_0046653Biological processtetrahydrofolate metabolic process
GO_0009396Biological processfolic acid-containing compound biosynthetic process
GO_0035999Biological processtetrahydrofolate interconversion
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0030272Molecular function5-formyltetrahydrofolate cyclo-ligase activity
GO_0005542Molecular functionfolic acid binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMTHFS
Protein name5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2)
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)
Methenyltetrahydrofolate synthetase
Synonyms
DescriptionFUNCTION: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. .

AccessionsENST00000258874.4 [P49914-1]
P49914
ENST00000560261.1
ENST00000560919.5
ENST00000559722.2
Q96EE9
H3BN04
H3BMB9
A0A0U1RQM3