MRPL58 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MRPL58 at tissue level.

III. Associated gene sets

GO_0032543Biological processmitochondrial translation
GO_0070126Biological processmitochondrial translational termination
GO_0072344Biological processrescue of stalled ribosome
GO_0005762Cellular componentmitochondrial large ribosomal subunit
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005759Cellular componentmitochondrial matrix
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0016150Molecular functiontranslation release factor activity, codon nonspecific
GO_0004045Molecular functionaminoacyl-tRNA hydrolase activity

IV. Literature review

[source]
Gene nameMRPL58
Protein nameLarge ribosomal subunit protein mL62 (EC 3.1.1.29) (Peptidyl-tRNA hydrolase ICT1, mitochondrial)
Large ribosomal subunit protein mL62 (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein) (Peptidyl-tRNA hydrolase ICT1, mitochondrial) (EC 3.1.1.29)
Mitochondrial ribosomal protein L58
SynonymsDS1
ICT1
DescriptionFUNCTION: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit . Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation . Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes . .

AccessionsJ3KS15
J3QRF8
Q14197
ENST00000580800.1
ENST00000584208.5
ENST00000301585.10