MMP24 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010001Biological processglial cell differentiation
GO_0098742Biological processcell-cell adhesion via plasma-membrane adhesion molecules
GO_0030198Biological processextracellular matrix organization
GO_0030574Biological processcollagen catabolic process
GO_0097150Biological processneuronal stem cell population maintenance
GO_0050965Biological processdetection of temperature stimulus involved in sensory perception of pain
GO_0006508Biological processproteolysis
GO_0044331Biological processcell-cell adhesion mediated by cadherin
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0031012Cellular componentextracellular matrix
GO_0045296Molecular functioncadherin binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0008047Molecular functionenzyme activator activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMMP24
Protein nameAlternative protein MMP24
Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24]
MMP24 protein
SynonymsMT5MMP
DescriptionFUNCTION: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). .

AccessionsENST00000246186.8
L8E8C1
Q86VV6
Q9Y5R2