MMP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MMP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MMP1 at tissue level.

III. Associated gene sets

GO_0030198Biological processextracellular matrix organization
GO_0022617Biological processextracellular matrix disassembly
GO_0030574Biological processcollagen catabolic process
GO_0006508Biological processproteolysis
GO_0071492Biological processcellular response to UV-A
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0019538Biological processprotein metabolic process
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0031012Cellular componentextracellular matrix
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameMMP1
Protein nameAlternative protein MMP1
Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]
Matrix metalloproteinase 1
interstitial collagenase (EC 3.4.24.7)
SynonymsCLG
DescriptionFUNCTION: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X . In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity . .

AccessionsA5GZ69
L8EC95
P03956
ENST00000315274.7
Q96DZ4