MMEL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MMEL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MMEL1 at tissue level.

III. Associated gene sets

GO_0016485Biological processprotein processing
GO_0006508Biological processproteolysis
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameMMEL1
Protein nameMembrane metallo-endopeptidase-like 1 (Membrane metalloendopeptidase like 1)
Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]
SynonymsMELL1
MMEL2
NEP2
DescriptionFUNCTION: Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). .

AccessionsENST00000621908.3 [Q495T6-3]
J3KRD2
ENST00000611357.4 [Q495T6-1]
ENST00000502556.5 [Q495T6-3]
Q495T6
ENST00000504800.5 [Q495T6-2]
ENST00000628503.2 [Q495T6-2]
ENST00000471840.5
ENST00000629675.2
ENST00000378412.8 [Q495T6-1]