MLYCD report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MLYCD at tissue level.

III. Associated gene sets

GO_0007584Biological processresponse to nutrient
GO_0019395Biological processfatty acid oxidation
GO_0031998Biological processregulation of fatty acid beta-oxidation
GO_0006633Biological processfatty acid biosynthetic process
GO_0010906Biological processregulation of glucose metabolic process
GO_0002931Biological processresponse to ischemia
GO_0006085Biological processacetyl-CoA biosynthetic process
GO_2001294Biological processmalonyl-CoA catabolic process
GO_0006637Biological processacyl-CoA metabolic process
GO_0046321Biological processpositive regulation of fatty acid oxidation
GO_0005829Cellular componentcytosol
GO_0005777Cellular componentperoxisome
GO_0005782Cellular componentperoxisomal matrix
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0050080Molecular functionmalonyl-CoA decarboxylase activity
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameMLYCD
Protein nameMalonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9)
Malonyl-CoA decarboxylase
Synonyms
DescriptionFUNCTION: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. .

AccessionsENST00000566309.2
ENST00000563312.5
ENST00000561562.5
V9GYW3
A0A087X1B8
ENST00000262430.6 [O95822-1]
O95822
V9GY18