I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 45% ± 15% | |
| epithelial cell | 3 studies | 27% ± 8% | |
| GABAergic neuron | 3 studies | 46% ± 2% | |
| astrocyte | 3 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 45% ± 15% | |
| epithelial cell | 3 studies | 27% ± 8% | |
| GABAergic neuron | 3 studies | 46% ± 2% | |
| astrocyte | 3 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 37% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 1305.73 | 459 / 459 | 100% | 6.96 | 1118 / 1118 |
| esophagus | 100% | 1169.12 | 1445 / 1445 | 100% | 6.29 | 183 / 183 |
| lung | 100% | 1145.87 | 577 / 578 | 100% | 6.19 | 1155 / 1155 |
| ovary | 100% | 1564.76 | 180 / 180 | 100% | 4.10 | 429 / 430 |
| kidney | 100% | 975.91 | 89 / 89 | 100% | 7.03 | 898 / 901 |
| bladder | 100% | 1292.43 | 21 / 21 | 100% | 5.75 | 502 / 504 |
| prostate | 100% | 1401.27 | 245 / 245 | 100% | 5.60 | 500 / 502 |
| brain | 100% | 1123.10 | 2631 / 2642 | 100% | 7.95 | 705 / 705 |
| adrenal gland | 100% | 1257.41 | 258 / 258 | 100% | 5.86 | 229 / 230 |
| uterus | 100% | 1567.14 | 170 / 170 | 100% | 5.57 | 457 / 459 |
| liver | 100% | 890.34 | 226 / 226 | 100% | 3.90 | 404 / 406 |
| thymus | 100% | 1538.22 | 653 / 653 | 99% | 6.85 | 601 / 605 |
| stomach | 100% | 1126.42 | 359 / 359 | 99% | 5.21 | 284 / 286 |
| intestine | 100% | 1511.99 | 966 / 966 | 99% | 5.24 | 522 / 527 |
| pancreas | 100% | 1085.28 | 328 / 328 | 99% | 5.77 | 176 / 178 |
| skin | 100% | 1347.13 | 1808 / 1809 | 94% | 4.26 | 443 / 472 |
| adipose | 100% | 1084.92 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1223.19 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 3.69 | 29 / 29 |
| spleen | 100% | 1757.95 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 5.06 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.42 | 1 / 1 |
| muscle | 98% | 522.18 | 784 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 525.77 | 835 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 65% | 411.94 | 607 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 61% | 2.01 | 49 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007040 | Biological process | lysosome organization |
| GO_1905165 | Biological process | regulation of lysosomal protein catabolic process |
| GO_0010506 | Biological process | regulation of autophagy |
| GO_0097352 | Biological process | autophagosome maturation |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0015705 | Biological process | iodide transport |
| GO_1903424 | Biological process | fluoride transmembrane transport |
| GO_0048666 | Biological process | neuron development |
| GO_0038202 | Biological process | TORC1 signaling |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0034707 | Cellular component | chloride channel complex |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0062054 | Molecular function | fluoride channel activity |
| GO_0015111 | Molecular function | iodide transmembrane transporter activity |
| GO_0005254 | Molecular function | chloride channel activity |
| Gene name | MFSD8 |
| Protein name | Major facilitator superfamily domain containing 8 Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7) Major facilitator superfamily domain containing 8 (cDNA FLJ50490) |
| Synonyms | MGC33302 CLN7 hCG_1778573 |
| Description | FUNCTION: Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions. . |
| Accessions | ENST00000641870.1 A0A286YFB5 ENST00000641434.1 [Q8NHS3-1] A0A286YEW8 ENST00000641025.1 A0A286YF00 ENST00000641509.1 A0A286YEV4 ENST00000641464.1 [Q8NHS3-2] ENST00000641928.1 [Q8NHS3-2] ENST00000641134.1 A0A286YFE7 ENST00000641482.1 ENST00000641092.1 A0A286YEX1 ENST00000641447.1 ENST00000641742.1 ENST00000641830.1 ENST00000641753.1 A0A286YF82 ENST00000641147.1 ENST00000641178.1 A0A286YFM7 ENST00000641369.1 ENST00000513559.6 ENST00000641686.2 [Q8NHS3-1] ENST00000509826.2 A0A286YEY8 ENST00000641393.1 A0A286YFC6 ENST00000641228.1 ENST00000641695.1 A0A286YF51 E7ERQ4 A0A286YFG7 B7Z2B2 ENST00000641748.1 [Q8NHS3-1] ENST00000641774.1 A0A286YFH9 ENST00000641397.1 A0A286YF72 ENST00000641690.1 ENST00000642034.1 ENST00000641503.1 ENST00000641508.1 ENST00000642042.1 A0A286YF93 A0A286YFM2 A0A286YF73 ENST00000641133.1 ENST00000641869.1 ENST00000641882.1 ENST00000641590.1 ENST00000641776.1 A0A286YFH3 ENST00000641413.1 ENST00000641743.1 A0A286YEW2 A0A286YFE6 A0A286YF45 ENST00000296468.8 [Q8NHS3-1] ENST00000641843.1 A0A286YFK4 ENST00000515130.6 A0A286YFJ5 A0A286YFI8 A0A286YEW7 ENST00000641243.1 ENST00000641264.1 A0A286YER2 ENST00000641658.1 ENST00000641340.1 ENST00000642078.1 Q8NHS3 A0A286YEW6 A0A286YFF1 ENST00000641949.1 A0A286YFF5 ENST00000641186.1 A0A286YEV9 ENST00000641558.1 ENST00000641332.1 ENST00000641538.1 A0A286YFI9 |
