MFSD2B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MFSD2B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MFSD2B at tissue level.

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0008643Biological processcarbohydrate transport
GO_0003376Biological processsphingosine-1-phosphate receptor signaling pathway
GO_1901731Biological processpositive regulation of platelet aggregation
GO_0055085Biological processtransmembrane transport
GO_0006869Biological processlipid transport
GO_0005886Cellular componentplasma membrane
GO_0015293Molecular functionsymporter activity
GO_0046624Molecular functionsphingolipid transporter activity

IV. Literature review

[source]
Gene nameMFSD2B
Protein nameMFSD2 lysolipid transporter B, sphingolipid
Sphingosine-1-phosphate transporter MFSD2B (Major facilitator superfamily domain-containing protein 2B) (hMfsd2b)
Synonyms
DescriptionFUNCTION: Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets . Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (By similarity). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (Probable). Release of sphingosine-1-phosphate is facilitated by a proton gradient (By similarity). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (Probable). In addition to export, also able to mediate S1P import (By similarity). Does not transport lysophosphatidylcholine (LPC) (Probable). .

AccessionsH7BZN4
ENST00000669179.1
A6NFX1
A0A2I3JL00
A0A590UK14
ENST00000453731.1
ENST00000338315.6
ENST00000406420.7