MFSD12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048022Biological processnegative regulation of melanin biosynthetic process
GO_0043474Biological processpigment metabolic process involved in pigmentation
GO_0008643Biological processcarbohydrate transport
GO_0048021Biological processregulation of melanin biosynthetic process
GO_1903712Biological processcysteine transmembrane transport
GO_0042438Biological processmelanin biosynthetic process
GO_0033162Cellular componentmelanosome membrane
GO_0005764Cellular componentlysosome
GO_0005886Cellular componentplasma membrane
GO_0042470Cellular componentmelanosome
GO_0005765Cellular componentlysosomal membrane
GO_0005770Cellular componentlate endosome
GO_0005215Molecular functiontransporter activity
GO_0015293Molecular functionsymporter activity
GO_0033229Molecular functioncysteine transmembrane transporter activity

IV. Literature review

[source]
Gene nameMFSD12
Protein nameMajor facilitator superfamily domain-containing protein 12
Major facilitator superfamily domain containing 12
SynonymsC19orf28
DescriptionFUNCTION: Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation . In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation . Also catalyzes import of cysteine into lysosomes in non-pigmented cells, regulating lysosomal cystine and cysteine storage, which is essnetial for redox homeostasis . .

AccessionsENST00000592652.1
K7ERJ8
ENST00000615073.4
K7ENE1
A0A0A0MS91
ENST00000589063.5
ENST00000355415.7 [Q6NUT3-1]
Q6NUT3
ENST00000398558.8
ENST00000589995.1
A0A087WU85
K7EKU1
K7EJS5
ENST00000588626.1
ENST00000588918.5 [Q6NUT3-2]
K7EQ22
ENST00000585814.1