Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 5 studies | 18% ± 3% | |
epithelial cell | 5 studies | 22% ± 3% | |
astrocyte | 4 studies | 34% ± 9% | |
glutamatergic neuron | 4 studies | 34% ± 11% | |
oligodendrocyte | 4 studies | 24% ± 7% | |
endothelial cell | 3 studies | 21% ± 5% | |
GABAergic neuron | 3 studies | 38% ± 3% | |
oligodendrocyte precursor cell | 3 studies | 22% ± 4% | |
transit amplifying cell | 3 studies | 29% ± 13% | |
memory B cell | 3 studies | 17% ± 1% | |
abnormal cell | 3 studies | 33% ± 9% | |
microglial cell | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1381.84 | 1445 / 1445 | 100% | 11.46 | 183 / 183 |
brain | 100% | 871.62 | 2639 / 2642 | 100% | 7.68 | 704 / 705 |
breast | 100% | 923.57 | 459 / 459 | 99% | 7.97 | 1112 / 1118 |
prostate | 100% | 1007.69 | 245 / 245 | 99% | 7.07 | 499 / 502 |
lung | 99% | 669.61 | 573 / 578 | 99% | 7.35 | 1141 / 1155 |
uterus | 100% | 892.00 | 170 / 170 | 98% | 6.92 | 449 / 459 |
ovary | 100% | 797.61 | 180 / 180 | 98% | 5.44 | 420 / 430 |
bladder | 100% | 1144.19 | 21 / 21 | 97% | 6.41 | 490 / 504 |
intestine | 100% | 1417.44 | 966 / 966 | 97% | 6.60 | 510 / 527 |
skin | 100% | 1940.13 | 1809 / 1809 | 94% | 7.45 | 442 / 472 |
stomach | 95% | 567.00 | 341 / 359 | 98% | 6.76 | 279 / 286 |
kidney | 100% | 573.65 | 89 / 89 | 87% | 4.19 | 787 / 901 |
pancreas | 91% | 320.42 | 299 / 328 | 95% | 4.55 | 169 / 178 |
adrenal gland | 100% | 912.30 | 258 / 258 | 82% | 3.00 | 189 / 230 |
thymus | 100% | 606.65 | 652 / 653 | 70% | 2.53 | 422 / 605 |
liver | 98% | 388.59 | 222 / 226 | 52% | 1.93 | 210 / 406 |
adipose | 100% | 952.17 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 754.12 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1373.18 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 9.40 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.75 | 1 / 1 |
muscle | 99% | 494.07 | 794 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 8.12 | 27 / 29 |
heart | 92% | 436.44 | 794 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 65% | 3.25 | 52 / 80 |
peripheral blood | 54% | 877.78 | 498 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070131 | Biological process | positive regulation of mitochondrial translation |
GO_0016071 | Biological process | mRNA metabolic process |
GO_0106217 | Biological process | tRNA C3-cytosine methylation |
GO_0070900 | Biological process | mitochondrial tRNA modification |
GO_0005737 | Cellular component | cytoplasm |
GO_0005739 | Cellular component | mitochondrion |
GO_0005634 | Cellular component | nucleus |
GO_0052735 | Molecular function | tRNA (cytidine-3-)-methyltransferase activity |
GO_0008174 | Molecular function | mRNA methyltransferase activity |
Gene name | METTL8 |
Protein name | tRNA N(3)-methylcytidine methyltransferase (EC 2.1.1.-) Methyltransferase 8, methylcytidine tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial (EC 2.1.1.-) (Methyltransferase-like protein 8) (mRNA N(3)-methylcytidine methyltransferase METTL8) (EC 2.1.1.-) |
Synonyms | hCG_2004932 FLJ13984 |
Description | FUNCTION: Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) . N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain . N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite . May also mediate N(3)-methylcytidine modification of mRNAs . The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo . . FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase. . |
Accessions | ENST00000392604.6 [Q9H825-1] ENST00000442541.1 B3KW44 Q9H825 ENST00000453846.5 ENST00000438609.6 C9JE69 ENST00000442778.5 H7C2P8 C9J3F1 ENST00000447486.5 [Q9H825-2] B5ME25 ENST00000612742.5 ENST00000392599.6 ENST00000375258.9 C9J6U8 |