METTL8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070131Biological processpositive regulation of mitochondrial translation
GO_0016071Biological processmRNA metabolic process
GO_0106217Biological processtRNA C3-cytosine methylation
GO_0070900Biological processmitochondrial tRNA modification
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0052735Molecular functiontRNA (cytidine-3-)-methyltransferase activity
GO_0008174Molecular functionmRNA methyltransferase activity

IV. Literature review

[source]
Gene nameMETTL8
Protein nametRNA N(3)-methylcytidine methyltransferase (EC 2.1.1.-)
Methyltransferase 8, methylcytidine
tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial (EC 2.1.1.-) (Methyltransferase-like protein 8) (mRNA N(3)-methylcytidine methyltransferase METTL8) (EC 2.1.1.-)
SynonymshCG_2004932
FLJ13984
DescriptionFUNCTION: Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) . N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain . N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite . May also mediate N(3)-methylcytidine modification of mRNAs . The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo . .

FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase. .

AccessionsENST00000392604.6 [Q9H825-1]
ENST00000442541.1
B3KW44
Q9H825
ENST00000453846.5
ENST00000438609.6
C9JE69
ENST00000442778.5
H7C2P8
C9J3F1
ENST00000447486.5 [Q9H825-2]
B5ME25
ENST00000612742.5
ENST00000392599.6
ENST00000375258.9
C9J6U8