MEGF10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014841Biological processskeletal muscle satellite cell proliferation
GO_0014816Biological processskeletal muscle satellite cell differentiation
GO_0055001Biological processmuscle cell development
GO_0051147Biological processregulation of muscle cell differentiation
GO_0033002Biological processmuscle cell proliferation
GO_2000288Biological processpositive regulation of myoblast proliferation
GO_0034109Biological processhomotypic cell-cell adhesion
GO_0043277Biological processapoptotic cell clearance
GO_0048641Biological processregulation of skeletal muscle tissue development
GO_0014719Biological processskeletal muscle satellite cell activation
GO_1902742Biological processapoptotic process involved in development
GO_0048627Biological processmyoblast development
GO_0051451Biological processmyoblast migration
GO_0043654Biological processrecognition of apoptotic cell
GO_0043652Biological processengulfment of apoptotic cell
GO_0022409Biological processpositive regulation of cell-cell adhesion
GO_0005886Cellular componentplasma membrane
GO_0001891Cellular componentphagocytic cup
GO_0042995Cellular componentcell projection
GO_0005112Molecular functionNotch binding
GO_0005044Molecular functionscavenger receptor activity
GO_0001849Molecular functioncomplement component C1q complex binding

IV. Literature review

[source]
Gene nameMEGF10
Protein nameMultiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)
SynonymsKIAA1780
DescriptionFUNCTION: Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells . Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides . Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum . Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway . May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements . .

AccessionsENST00000508365.5 [Q96KG7-2]
Q96KG7
ENST00000503335.7 [Q96KG7-1]
ENST00000418761.6 [Q96KG7-2]
ENST00000274473.6 [Q96KG7-1]