MBLAC1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MBLAC1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MBLAC1 at tissue level.

III. Associated gene sets

GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0031124Biological processmRNA 3'-end processing
GO_0008334Biological processhistone mRNA metabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004521Molecular functionRNA endonuclease activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameMBLAC1
Protein nameMetallo-beta-lactamase domain containing 1
Metallo-beta-lactamase domain-containing protein 1 (EC 3.1.27.-) (Endoribonuclease MBLAC1)
Synonyms
DescriptionFUNCTION: Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase . Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop . May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage . .

AccessionsENST00000398075.4
A4D2B0
C9JAV3
ENST00000421390.1