I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 6 studies | 47% ± 20% | |
| GABAergic neuron | 6 studies | 43% ± 21% | |
| interneuron | 5 studies | 51% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 6 studies | 47% ± 20% | |
| GABAergic neuron | 6 studies | 43% ± 21% | |
| interneuron | 5 studies | 51% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 51% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 86% | 788.78 | 2279 / 2642 | 70% | 8.42 | 491 / 705 |
| adrenal gland | 12% | 30.39 | 31 / 258 | 68% | 21.64 | 157 / 230 |
| pancreas | 11% | 17.10 | 37 / 328 | 48% | 2.89 | 85 / 178 |
| skin | 30% | 566.53 | 542 / 1809 | 4% | 0.40 | 18 / 472 |
| kidney | 1% | 1.56 | 1 / 89 | 23% | 0.54 | 206 / 901 |
| stomach | 9% | 12.84 | 32 / 359 | 7% | 0.21 | 19 / 286 |
| thymus | 0% | 0.26 | 1 / 653 | 12% | 0.28 | 71 / 605 |
| bladder | 0% | 0 | 0 / 21 | 10% | 0.95 | 52 / 504 |
| lung | 3% | 5.68 | 20 / 578 | 7% | 0.60 | 78 / 1155 |
| esophagus | 0% | 0 | 0 / 1445 | 9% | 0.26 | 17 / 183 |
| uterus | 1% | 0.96 | 1 / 170 | 8% | 0.31 | 36 / 459 |
| intestine | 1% | 1.60 | 12 / 966 | 6% | 0.34 | 33 / 527 |
| breast | 0% | 0 | 0 / 459 | 7% | 0.62 | 78 / 1118 |
| prostate | 0% | 0 | 0 / 245 | 4% | 0.23 | 20 / 502 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| ovary | 0% | 0 | 0 / 180 | 3% | 0.14 | 14 / 430 |
| blood vessel | 2% | 3.42 | 28 / 1335 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.03 | 6 / 406 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.03 | 1 / 80 |
| spleen | 0% | 0.51 | 1 / 241 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.12 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0005802 | Cellular component | trans-Golgi network |
| GO_0005795 | Cellular component | Golgi stack |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | MARCHF4 |
| Protein name | E3 ubiquitin-protein ligase MARCHF4 (EC 2.3.2.27) (Membrane-associated RING finger protein 4) (Membrane-associated RING-CH protein IV) (MARCH-IV) (RING finger protein 174) (RING-type E3 ubiquitin transferase MARCHF4) |
| Synonyms | KIAA1399 MARCH4 RNF174 |
| Description | FUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. . |
| Accessions | Q9P2E8 ENST00000273067.5 |
