MAP1LC3B2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MAP1LC3B2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAP1LC3B2 at tissue level.

III. Associated gene sets

GO_0000422Biological processautophagy of mitochondrion
GO_0097352Biological processautophagosome maturation
GO_0006995Biological processcellular response to nitrogen starvation
GO_0000045Biological processautophagosome assembly
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000421Cellular componentautophagosome membrane
GO_0005874Cellular componentmicrotubule
GO_0031410Cellular componentcytoplasmic vesicle
GO_0012505Cellular componentendomembrane system
GO_0008017Molecular functionmicrotubule binding
GO_0008429Molecular functionphosphatidylethanolamine binding
GO_0031625Molecular functionubiquitin protein ligase binding

IV. Literature review

[source]
Gene nameMAP1LC3B2
Protein nameMicrotubule-associated proteins 1A/1B light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3B-like)
Synonyms
DescriptionFUNCTION: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. .

AccessionsA6NCE7
ENST00000556529.4