LPO | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of LPO at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	82%	21.94	2164 / 2642	1%	0.01	7 / 705
spleen	76%	19.45	182 / 241	0%	0	0 / 0
peripheral blood	56%	9.99	524 / 929	0%	0	0 / 0
lung	43%	10.34	248 / 578	5%	0.14	54 / 1155
ovary	7%	0.47	13 / 180	29%	0.88	126 / 430
breast	28%	21.47	130 / 459	5%	0.24	59 / 1118
skin	25%	3.00	450 / 1809	1%	1.29	3 / 472
pancreas	23%	1.55	75 / 328	0%	0	0 / 178
intestine	15%	1.63	147 / 966	6%	0.17	30 / 527
esophagus	16%	13.90	224 / 1445	3%	0.07	6 / 183
adrenal gland	16%	4.26	41 / 258	1%	0.01	2 / 230
prostate	17%	1.07	41 / 245	0%	0	0 / 502
kidney	16%	1.33	14 / 89	0%	0.01	3 / 901
uterus	13%	1.94	22 / 170	3%	0.07	12 / 459
liver	13%	1.00	30 / 226	1%	0.09	6 / 406
stomach	7%	0.64	25 / 359	8%	0.20	22 / 286
thymus	14%	1.00	92 / 653	0%	0.01	1 / 605
adipose	13%	11.03	155 / 1204	0%	0	0 / 0
bladder	10%	0.43	2 / 21	2%	0.07	10 / 504
heart	9%	1.04	75 / 861	0%	0	0 / 0
muscle	6%	0.90	45 / 803	0%	0	0 / 0
blood vessel	5%	0.69	67 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.08	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0018969	Biological process	thiocyanate metabolic process
GO_0042744	Biological process	hydrogen peroxide catabolic process
GO_0001580	Biological process	detection of chemical stimulus involved in sensory perception of bitter taste
GO_0098869	Biological process	cellular oxidant detoxification
GO_0006979	Biological process	response to oxidative stress
GO_0042742	Biological process	defense response to bacterium
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005615	Cellular component	extracellular space
GO_0070062	Cellular component	extracellular exosome
GO_0005576	Cellular component	extracellular region
GO_0005737	Cellular component	cytoplasm
GO_0140825	Molecular function	lactoperoxidase activity
GO_0020037	Molecular function	heme binding
GO_0036393	Molecular function	thiocyanate peroxidase activity
GO_0046872	Molecular function	metal ion binding

Gene name	LPO
Protein name	Lactoperoxidase (LPO) (EC 1.11.1.7) (Salivary peroxidase) (SPO) Lactoperoxidase
Synonyms	SAPX
Description	FUNCTION: Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism . Shows antibacterial properties against Pseudomonas aeruginosa . The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against Burkholderia cepacia and Haemophilus influenzae in vitro . Present in mammary and salivary gland secretions and may contribute to airway host defense against infection . May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity). .
Accessions	F5H386 ENST00000543544.5 ENST00000262290.9 [P22079-1] ENST00000389576.4 H0Y3I2 ENST00000580890.5 ENST00000581008.1 J3KT11 J3QSD8 P22079 ENST00000582328.5 [P22079-2] ENST00000421678.6 [P22079-2]

LPO report