LCT report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LCT at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LCT at tissue level.

III. Associated gene sets

GO_1901733Biological processquercetin catabolic process
GO_0046477Biological processglycosylceramide catabolic process
GO_2000892Biological processcellobiose catabolic process
GO_0005990Biological processlactose catabolic process
GO_0098591Cellular componentexternal side of apical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0004336Molecular functiongalactosylceramidase activity
GO_0000016Molecular functionlactase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0140749Molecular functionphlorizin hydrolase activity
GO_0008422Molecular functionbeta-glucosidase activity
GO_0080079Molecular functioncellobiose glucosidase activity
GO_0017042Molecular functionglycosylceramidase activity
GO_0004348Molecular functionglucosylceramidase activity

IV. Literature review

[source]
Gene nameLCT
Protein nameLactase-phlorizin hydrolase-1
Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)]
LCT
Lactase
SynonymsLPH
DescriptionFUNCTION: Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose . The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other . .

AccessionsQ6Y1I9
H0Y4E4
Q45V77
P09848
ENST00000264162.7
ENST00000452974.1