KPTN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KPTN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KPTN at tissue level.

III. Associated gene sets

GO_0034198Biological processcellular response to amino acid starvation
GO_0042149Biological processcellular response to glucose starvation
GO_0061462Biological processprotein localization to lysosome
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0007015Biological processactin filament organization
GO_0140007Cellular componentKICSTOR complex
GO_0032420Cellular componentstereocilium
GO_0098871Cellular componentpostsynaptic actin cytoskeleton
GO_0030027Cellular componentlamellipodium
GO_0031941Cellular componentfilamentous actin
GO_0005765Cellular componentlysosomal membrane
GO_0051015Molecular functionactin filament binding

IV. Literature review

[source]
Gene nameKPTN
Protein nameKICSTOR complex protein kaptin (Actin-associated protein 2E4)
Kaptin, actin binding protein
Synonyms
DescriptionFUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. .

AccessionsM0QZ83
M0R238
ENST00000595554.1
ENST00000594208.5
ENST00000600271.5
ENST00000338134.8 [Q9Y664-1]
M0QXX4
Q9Y664