KLK7 | OmnibusX

Name	Number of supported studies	Average coverage
squamous epithelial cell	3 studies	30% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of KLK7 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	36%	2798.56	525 / 1445	65%	74.75	119 / 183
ovary	0%	0	0 / 180	97%	403.86	419 / 430
skin	73%	11346.14	1320 / 1809	10%	14.02	45 / 472
kidney	70%	892.64	62 / 89	0%	0.17	3 / 901
pancreas	0%	0	0 / 328	63%	81.17	113 / 178
thymus	0%	0	0 / 653	54%	52.47	325 / 605
breast	33%	443.35	152 / 459	19%	16.42	212 / 1118
brain	29%	430.53	774 / 2642	4%	0.86	29 / 705
tonsil	0%	0	0 / 0	31%	31.73	14 / 45
uterus	4%	79.46	6 / 170	26%	19.75	120 / 459
lung	2%	15.62	9 / 578	21%	13.78	242 / 1155
intestine	0%	0	0 / 966	22%	16.23	116 / 527
stomach	1%	2.89	2 / 359	20%	11.45	58 / 286
adipose	21%	275.35	247 / 1204	0%	0	0 / 0
bladder	0%	0	0 / 21	15%	10.39	74 / 504
liver	0%	2.08	1 / 226	0%	0.10	2 / 406
adrenal gland	0%	3.18	1 / 258	0%	0.05	1 / 230
prostate	1%	4.22	2 / 245	0%	0	0 / 502
blood vessel	0%	11.34	4 / 1335	0%	0	0 / 0
muscle	0%	2.64	2 / 803	0%	0	0 / 0
heart	0%	0.65	1 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0002803	Biological process	positive regulation of antibacterial peptide production
GO_0022617	Biological process	extracellular matrix disassembly
GO_0008544	Biological process	epidermis development
GO_0006508	Biological process	proteolysis
GO_0001533	Cellular component	cornified envelope
GO_0005615	Cellular component	extracellular space
GO_0030141	Cellular component	secretory granule
GO_0005576	Cellular component	extracellular region
GO_0097209	Cellular component	epidermal lamellar body
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0008236	Molecular function	serine-type peptidase activity
GO_0008233	Molecular function	peptidase activity
GO_0004252	Molecular function	serine-type endopeptidase activity

Gene name	KLK7
Protein name	Kallikrein 7 splice variant 3 (Kallikrein related peptidase 7) Kallikrein-7 isoform 4 Kallikrein-7 isoform 5 Kallikrein related peptidase 7 Kallikrein 7 Kallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE)
Synonyms	PRSS6 SCCE hK7
Description	FUNCTION: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-\|-Gln-15' and insulin B chain at '6-Leu-\|-Cys-7', '16-Tyr-\|-Leu-17', '25-Phe-\|-Tyr-26' and '26-Tyr-\|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. .
Accessions	X2J4X7 ENST00000597707.5 [P49862-2] A0A2H4GDB6 ENST00000595820.6 [P49862-1] M0QYU8 Q6DTY1 ENST00000391807.5 [P49862-1] X2J289 ENST00000304045.6 P49862 ENST00000593904.1 A0A2H4GDB2

KLK7 report