KICS2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KICS2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KICS2 at tissue level.

III. Associated gene sets

GO_0042149Biological processcellular response to glucose starvation
GO_0061462Biological processprotein localization to lysosome
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0034198Biological processcellular response to amino acid starvation
GO_0140007Cellular componentKICSTOR complex
GO_0005764Cellular componentlysosome
GO_0005765Cellular componentlysosomal membrane
GO_0045171Cellular componentintercellular bridge

IV. Literature review

[source]
Gene nameKICS2
Protein nameKICSTOR subunit 2
KICSTOR subunit 2 (KICSTOR complex protein C12orf66)
SynonymsC12orf66
DescriptionFUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. .

AccessionsQ96MD2
ENST00000544871.1
ENST00000398055.8
F5H2Q3
ENST00000311915.12
J3KNH0