KCTD11 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCTD11 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCTD11 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0016567Biological processprotein ubiquitination
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0016740Molecular functiontransferase activity
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameKCTD11
Protein namePotassium channel tetramerisation domain containing 11
BTB/POZ domain-containing protein KCTD11 (KCASH1 protein) (Potassium channel tetramerization domain-containing protein 11) (RING-type E3 ubiquitin transferase subunit KCTD11)
BTB/POZ domain-containing protein KCTD11
SynonymsC17orf36
REN
DescriptionFUNCTION: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. .

AccessionsENST00000333751
Q693B1
ENST00000333751.8 [Q693B1-2]
ENST00000672140.1 [Q693B1-1]
ENST00000576980.2 [Q693B1-1]
ENST00000673447.2 [Q693B1-2]
A0A2U3TZI5
A0A158RFT7