I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 6 studies | 27% ± 5% | |
| GABAergic neuron | 4 studies | 29% ± 16% | |
| type I pneumocyte | 3 studies | 17% ± 1% | |
| interneuron | 3 studies | 38% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 6 studies | 27% ± 5% | |
| GABAergic neuron | 4 studies | 29% ± 16% | |
| type I pneumocyte | 3 studies | 17% ± 1% | |
| interneuron | 3 studies | 38% ± 15% |
Insufficient scRNA-seq data for expression of KCNS3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 2599.22 | 578 / 578 | 91% | 49.36 | 1056 / 1155 |
| breast | 93% | 673.11 | 429 / 459 | 96% | 43.16 | 1078 / 1118 |
| pancreas | 98% | 559.44 | 322 / 328 | 89% | 20.06 | 158 / 178 |
| prostate | 98% | 750.30 | 240 / 245 | 86% | 17.70 | 434 / 502 |
| kidney | 94% | 387.44 | 84 / 89 | 84% | 21.81 | 760 / 901 |
| bladder | 100% | 764.48 | 21 / 21 | 74% | 20.34 | 371 / 504 |
| uterus | 89% | 412.79 | 151 / 170 | 80% | 23.39 | 368 / 459 |
| esophagus | 99% | 777.73 | 1435 / 1445 | 68% | 20.06 | 124 / 183 |
| intestine | 99% | 1096.96 | 959 / 966 | 57% | 9.05 | 301 / 527 |
| stomach | 99% | 877.15 | 357 / 359 | 57% | 7.81 | 162 / 286 |
| skin | 91% | 483.98 | 1652 / 1809 | 61% | 15.25 | 288 / 472 |
| thymus | 86% | 265.72 | 562 / 653 | 62% | 7.90 | 377 / 605 |
| ureter | 0% | 0 | 0 / 0 | 100% | 40.79 | 1 / 1 |
| muscle | 100% | 1943.47 | 801 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 97% | 879.33 | 1301 / 1335 | 0% | 0 | 0 / 0 |
| brain | 72% | 320.35 | 1907 / 2642 | 24% | 3.20 | 168 / 705 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 34.38 | 43 / 45 |
| liver | 56% | 166.21 | 126 / 226 | 29% | 5.26 | 116 / 406 |
| heart | 82% | 378.63 | 703 / 861 | 0% | 0 | 0 / 0 |
| adipose | 79% | 279.87 | 954 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 75% | 12.44 | 60 / 80 |
| ovary | 24% | 66.63 | 43 / 180 | 43% | 5.68 | 185 / 430 |
| adrenal gland | 21% | 48.94 | 55 / 258 | 18% | 2.45 | 41 / 230 |
| spleen | 15% | 32.09 | 37 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.71 | 1 / 29 |
| peripheral blood | 0% | 1.36 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0051260 | Biological process | protein homooligomerization |
| GO_0006813 | Biological process | potassium ion transport |
| GO_0001508 | Biological process | action potential |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0005829 | Cellular component | cytosol |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0016020 | Cellular component | membrane |
| GO_0015459 | Molecular function | potassium channel regulator activity |
| GO_0005249 | Molecular function | voltage-gated potassium channel activity |
| GO_0005251 | Molecular function | delayed rectifier potassium channel activity |
| Gene name | KCNS3 |
| Protein name | Potassium voltage-gated channel subfamily S member 3 (Delayed-rectifier K(+) channel alpha subunit 3) (Voltage-gated potassium channel subunit Kv9.3) Potassium voltage-gated channel modifier subfamily S member 3 Alternative protein KCNS3 |
| Synonyms | |
| Description | FUNCTION: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 . Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity). . |
| Accessions | ENST00000419802.1 C9J187 L8E8W4 Q9BQ31 ENST00000403915.5 ENST00000304101.9 |
