KCNMB3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNMB3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNMB3 at tissue level.

III. Associated gene sets

GO_0006813Biological processpotassium ion transport
GO_0001508Biological processaction potential
GO_0019228Biological processneuronal action potential
GO_0071805Biological processpotassium ion transmembrane transport
GO_0005513Biological processdetection of calcium ion
GO_0005886Cellular componentplasma membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0015269Molecular functioncalcium-activated potassium channel activity
GO_0015459Molecular functionpotassium channel regulator activity

IV. Literature review

[source]
Gene nameKCNMB3
Protein nameCalcium-activated potassium channel subunit beta-3 (BK channel subunit beta-3) (BKbeta3) (Hbeta3) (Calcium-activated potassium channel, subfamily M subunit beta-3) (Charybdotoxin receptor subunit beta-3) (K(VCA)beta-3) (Maxi K channel subunit beta-3) (Slo-beta-3)
Alternative protein KCNMB3
Calcium-activated potassium channel subunit beta (BKbeta) (BK channel subunit beta) (Calcium-activated potassium channel, subfamily M subunit beta) (Charybdotoxin receptor subunit beta) (K(VCA)beta) (Maxi K channel subunit beta) (Slo-beta)
SynonymsKCNMBL
KCNMB2
DescriptionFUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. .

FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. .

AccessionsENST00000392686.6 [Q9NPA1-4]
ENST00000392685.7 [Q9NPA1-3]
ENST00000497599.5 [Q9NPA1-5]
ENST00000349697.2 [Q9NPA1-2]
A0A087WV41
ENST00000486944.2
ENST00000314235.9 [Q9NPA1-1]
L8E9P7
ENST00000485523.5 [Q9NPA1-4]
Q9NPA1