KCNK4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNK4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNK4 at tissue level.

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0007613Biological processmemory
GO_0030322Biological processstabilization of membrane potential
GO_0006813Biological processpotassium ion transport
GO_0071469Biological processcellular response to alkaline pH
GO_0050976Biological processdetection of mechanical stimulus involved in sensory perception of touch
GO_0071502Biological processcellular response to temperature stimulus
GO_0071260Biological processcellular response to mechanical stimulus
GO_0050951Biological processsensory perception of temperature stimulus
GO_0071805Biological processpotassium ion transmembrane transport
GO_0071398Biological processcellular response to fatty acid
GO_0034705Cellular componentpotassium channel complex
GO_0005886Cellular componentplasma membrane
GO_0005267Molecular functionpotassium channel activity
GO_0097604Molecular functiontemperature-gated cation channel activity
GO_0098782Molecular functionmechanosensitive potassium channel activity
GO_0022841Molecular functionpotassium ion leak channel activity
GO_0015271Molecular functionoutward rectifier potassium channel activity

IV. Literature review

[source]
Gene nameKCNK4
Protein namePotassium two pore domain channel subfamily K member 4
KCNK4 protein
Potassium channel subfamily K member 4 (TWIK-related arachidonic acid-stimulated potassium channel protein) (TRAAK) (Two pore potassium channel KT4.1) (Two pore K(+) channel KT4.1)
SynonymsTRAAK
DescriptionFUNCTION: Voltage-insensitive potassium channel . Channel opening is triggered by mechanical forces that deform the membrane . Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity). .

AccessionsENST00000541349.5
ENST00000539216.1 [Q9NYG8-1]
F5GZ20
ENST00000538767.1
Q9NYG8
ENST00000696753.1 [Q9NYG8-2]
ENST00000394525.6 [Q9NYG8-1]
F5GYE0
Q2YDA1
A3KMH3
ENST00000422670.7 [Q9NYG8-1]