KCNK18 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNK18 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNK18 at tissue level.

III. Associated gene sets

GO_0030322Biological processstabilization of membrane potential
GO_0006813Biological processpotassium ion transport
GO_0097623Biological processpotassium ion export across plasma membrane
GO_0071467Biological processcellular response to pH
GO_0071805Biological processpotassium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0015269Molecular functioncalcium-activated potassium channel activity
GO_0022841Molecular functionpotassium ion leak channel activity
GO_0015271Molecular functionoutward rectifier potassium channel activity

IV. Literature review

[source]
Gene nameKCNK18
Protein namePotassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel)
SynonymsTRESK
TRIK
DescriptionFUNCTION: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). .

AccessionsQ7Z418
ENST00000334549.1