KCNAB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
smooth muscle cell	13 studies	32% ± 16%	Explore
pericyte	10 studies	28% ± 17%	Explore
glutamatergic neuron	7 studies	44% ± 21%	Explore
oligodendrocyte precursor cell	7 studies	43% ± 18%	Explore
GABAergic neuron	6 studies	59% ± 26%	Explore
oligodendrocyte	6 studies	34% ± 13%	Explore
endothelial cell	4 studies	32% ± 8%	Explore
retinal bipolar neuron	4 studies	31% ± 15%	Explore
granule cell	4 studies	28% ± 1%	Explore
interneuron	3 studies	43% ± 27%	Explore
fibroblast	3 studies	23% ± 5%	Explore
astrocyte	3 studies	37% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	38% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	96%	4230.23	2529 / 2642	99%	8.65	701 / 705
thymus	99%	2024.46	647 / 653	89%	21.49	537 / 605
prostate	80%	1341.61	195 / 245	96%	6.11	483 / 502
breast	93%	1279.51	425 / 459	80%	2.17	896 / 1118
uterus	78%	832.39	132 / 170	32%	0.96	146 / 459
blood vessel	99%	8611.84	1321 / 1335	0%	0	0 / 0
pancreas	19%	96.21	63 / 328	76%	2.29	136 / 178
esophagus	36%	275.01	519 / 1445	58%	1.20	107 / 183
adipose	94%	1930.70	1134 / 1204	0%	0	0 / 0
lung	38%	256.88	222 / 578	51%	1.10	590 / 1155
adrenal gland	10%	62.73	26 / 258	77%	9.61	178 / 230
intestine	57%	556.36	547 / 966	22%	0.50	116 / 527
ovary	35%	392.72	63 / 180	43%	0.72	184 / 430
kidney	6%	38.56	5 / 89	71%	4.68	638 / 901
bladder	48%	384.90	10 / 21	21%	0.49	106 / 504
skin	15%	118.27	277 / 1809	52%	1.41	246 / 472
stomach	14%	109.25	52 / 359	40%	0.83	113 / 286
heart	31%	184.82	267 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	29%	0.37	13 / 45
spleen	24%	152.04	59 / 241	0%	0	0 / 0
liver	0%	0	0 / 226	23%	0.35	92 / 406
lymph node	0%	0	0 / 0	10%	0.15	3 / 29
muscle	8%	62.81	67 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	8%	0.21	6 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006813	Biological process	potassium ion transport
GO_1902259	Biological process	regulation of delayed rectifier potassium channel activity
GO_1903817	Biological process	negative regulation of voltage-gated potassium channel activity
GO_1901379	Biological process	regulation of potassium ion transmembrane transport
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0044224	Cellular component	juxtaparanode region of axon
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0034705	Cellular component	potassium channel complex
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0008076	Cellular component	voltage-gated potassium channel complex
GO_0044325	Molecular function	transmembrane transporter binding
GO_0070402	Molecular function	NADPH binding
GO_0015459	Molecular function	potassium channel regulator activity
GO_0004033	Molecular function	aldo-keto reductase (NADPH) activity
GO_0005249	Molecular function	voltage-gated potassium channel activity
GO_0019904	Molecular function	protein domain specific binding
GO_0140678	Molecular function	molecular function inhibitor activity

IV. Literature review

[source]

Gene name	KCNAB1
Protein name	Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) Potassium voltage-gated channel subfamily A regulatory beta subunit 1 Alternative protein KCNAB1 Potassium voltage-gated channel beta subunit Potassium voltage-gated channel subfamily A regulatory beta subunit 1 (cDNA FLJ59247, highly similar to Voltage-gated potassium channel subunit beta-1)
Synonyms	KCNA1B
Description	FUNCTION: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits . Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members . Promotes the closure of KCNA1, KCNA2 and KCNA5 channels . Accelerates KCNA4 channel closure . Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 . Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 . Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity . Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). .
Accessions	ENST00000475456.5 B7Z8E5 C9JQ60 Q5MJQ3 ENST00000618897.4 ENST00000490337.6 [Q14722-1] Q14722 A0A087X1P8 H7C4S9 ENST00000489036.5 L8E988 C9JBV8 ENST00000472028.5 F8W6W4 ENST00000389636.9 ENST00000302490.12 [Q14722-2] ENST00000389634.5 ENST00000471742.5 [Q14722-3]

KCNAB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review