I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 3 studies | 37% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 3 studies | 37% ± 15% |
Insufficient scRNA-seq data for expression of IL18BP at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 2660.89 | 578 / 578 | 99% | 16.92 | 1142 / 1155 |
| breast | 100% | 1321.82 | 459 / 459 | 97% | 11.76 | 1080 / 1118 |
| prostate | 100% | 1746.81 | 245 / 245 | 96% | 8.83 | 481 / 502 |
| thymus | 100% | 1498.15 | 653 / 653 | 96% | 8.45 | 578 / 605 |
| uterus | 100% | 1357.32 | 170 / 170 | 95% | 11.01 | 438 / 459 |
| esophagus | 100% | 941.88 | 1442 / 1445 | 96% | 13.76 | 175 / 183 |
| ovary | 100% | 1330.57 | 180 / 180 | 95% | 10.27 | 408 / 430 |
| kidney | 100% | 1921.81 | 89 / 89 | 95% | 19.63 | 854 / 901 |
| intestine | 100% | 1309.51 | 966 / 966 | 94% | 11.38 | 498 / 527 |
| skin | 99% | 713.21 | 1795 / 1809 | 95% | 22.63 | 449 / 472 |
| stomach | 99% | 843.48 | 357 / 359 | 94% | 14.69 | 270 / 286 |
| bladder | 100% | 1229.29 | 21 / 21 | 94% | 10.97 | 472 / 504 |
| brain | 94% | 663.42 | 2482 / 2642 | 99% | 15.89 | 699 / 705 |
| adrenal gland | 100% | 1427.48 | 258 / 258 | 92% | 13.36 | 212 / 230 |
| pancreas | 96% | 514.72 | 316 / 328 | 95% | 12.19 | 169 / 178 |
| liver | 98% | 675.21 | 222 / 226 | 81% | 8.09 | 327 / 406 |
| adipose | 100% | 1291.83 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 50.25 | 29 / 29 |
| spleen | 100% | 4207.99 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.28 | 1 / 1 |
| blood vessel | 100% | 964.27 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 556.43 | 834 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 16.17 | 43 / 45 |
| peripheral blood | 87% | 984.34 | 811 / 929 | 0% | 0 | 0 / 0 |
| muscle | 82% | 298.90 | 655 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 57% | 10.27 | 46 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071356 | Biological process | cellular response to tumor necrosis factor |
| GO_0042088 | Biological process | T-helper 1 type immune response |
| GO_0070301 | Biological process | cellular response to hydrogen peroxide |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0005615 | Cellular component | extracellular space |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005576 | Cellular component | extracellular region |
| GO_0048019 | Molecular function | receptor antagonist activity |
| GO_0042007 | Molecular function | interleukin-18 binding |
| Gene name | IL18BP |
| Protein name | Interleukin 18 binding protein Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa) |
| Synonyms | hCG_23241 |
| Description | FUNCTION: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. . |
| Accessions | ENST00000393707.4 [O95998-3] ENST00000620017.4 [O95998-4] ENST00000698839.1 [O95998-2] ENST00000393703.9 [O95998-2] ENST00000343898.9 [O95998-4] ENST00000698838.1 [O95998-2] ENST00000337131.9 [O95998-2] G3V1C5 ENST00000393705.8 [O95998-2] ENST00000404792.5 [O95998-2] O95998 ENST00000698840.1 [O95998-2] A0A8V8TP32 ENST00000497194.6 ENST00000698841.1 ENST00000698837.1 [O95998-2] ENST00000534583.5 [O95998-2] ENST00000531053.5 |
