IGHV5-51 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IGHV5-51 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IGHV5-51 at tissue level.

III. Associated gene sets

GO_0016064Biological processimmunoglobulin mediated immune response
GO_0019814Cellular componentimmunoglobulin complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0003823Molecular functionantigen binding

IV. Literature review

[source]
Gene nameIGHV5-51
Protein nameIGHV5-51*03_S2680
IGHV5-51 protein
Immunoglobulin heavy variable 5-51
Synonyms
DescriptionFUNCTION: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen . .

AccessionsENST00000390626.2
A0A449C189
A0A0F7TAV4
A0A0F7TB04
A0A0C4DH38
A0A0F7T891
A0A0F7T8B3
ENST00000620764.2