IGHV3-16 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IGHV3-16 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IGHV3-16 at tissue level.

III. Associated gene sets

GO_0016064Biological processimmunoglobulin mediated immune response
GO_0019814Cellular componentimmunoglobulin complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0003823Molecular functionantigen binding

IV. Literature review

[source]
Gene nameIGHV3-16
Protein nameProbable non-functional immunoglobulin heavy variable 3-16
Synonyms
DescriptionFUNCTION: Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen . .

AccessionsENST00000631755.1
ENST00000390604.2
A0A0C4DH30