HSD17B7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006703Biological processestrogen biosynthetic process
GO_0006695Biological processcholesterol biosynthetic process
GO_0008209Biological processandrogen metabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004303Molecular functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0047024Molecular function5alpha-androstane-3beta,17beta-diol dehydrogenase activity
GO_0000253Molecular function3-keto sterol reductase activity

IV. Literature review

[source]
Gene nameHSD17B7
Protein nameHydroxysteroid 17-beta dehydrogenase 7
HCG2024989, isoform CRA_g (Hydroxysteroid 17-beta dehydrogenase 7)
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1)
Synonyms17HSD7
hCG_2024989
UNQ2563/PRO6243
SDR37C1
DescriptionFUNCTION: Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis . Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) . Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol . Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation . Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase . .; FUNCTION: [Isoform 3]: Does not have enzymatic activities toward E1 and DHT. .

AccessionsP56937
ENST00000254521.8 [P56937-1]
ENST00000466176.5
V9GYN3
Q5T249
ENST00000367915.1
F2Z2C2
ENST00000470195.2