HKDC1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HKDC1 at tissue level.

III. Associated gene sets

GO_0046835Biological processcarbohydrate phosphorylation
GO_0051156Biological processglucose 6-phosphate metabolic process
GO_0006096Biological processglycolytic process
GO_0001678Biological processintracellular glucose homeostasis
GO_0006006Biological processglucose metabolic process
GO_0031966Cellular componentmitochondrial membrane
GO_0001917Cellular componentphotoreceptor inner segment
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005536Molecular functionD-glucose binding
GO_0004340Molecular functionglucokinase activity
GO_0005524Molecular functionATP binding
GO_0008865Molecular functionfructokinase activity

IV. Literature review

[source]
Gene nameHKDC1
Protein nameHexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1)
Synonyms
DescriptionFUNCTION: Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases . Has low glucose phosphorylating activity compared to other hexokinases . Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity). .

AccessionsENST00000354624.6 [Q2TB90-1]
Q2TB90