HAO1 | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	4 studies	51% ± 19%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of HAO1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	10793.50	226 / 226	90%	244.76	366 / 406
pancreas	77%	7.52	252 / 328	3%	0.60	5 / 178
kidney	78%	20.81	69 / 89	1%	0.13	7 / 901
prostate	44%	1.80	108 / 245	8%	1.20	39 / 502
peripheral blood	42%	26.86	390 / 929	0%	0	0 / 0
spleen	41%	17.75	98 / 241	0%	0	0 / 0
brain	39%	1.52	1023 / 2642	0%	0	0 / 705
stomach	36%	1.33	128 / 359	1%	0.37	3 / 286
lung	32%	1.64	187 / 578	0%	0.07	5 / 1155
muscle	29%	1.17	236 / 803	0%	0	0 / 0
intestine	24%	1.47	231 / 966	0%	0.44	2 / 527
adrenal gland	23%	0.78	60 / 258	0%	0	0 / 230
breast	21%	1.45	96 / 459	1%	0.25	10 / 1118
esophagus	20%	0.80	289 / 1445	0%	0	0 / 183
ovary	19%	0.54	35 / 180	0%	0	0 / 430
adipose	19%	2.14	233 / 1204	0%	0	0 / 0
thymus	19%	0.72	126 / 653	0%	0	0 / 605
heart	19%	0.91	165 / 861	0%	0	0 / 0
uterus	17%	0.65	29 / 170	0%	0.02	1 / 459
blood vessel	17%	0.73	226 / 1335	0%	0	0 / 0
skin	12%	0.59	214 / 1809	1%	0.17	4 / 472
bladder	5%	0.10	1 / 21	0%	0.02	1 / 504
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006545	Biological process	glycine biosynthetic process
GO_0006979	Biological process	response to oxidative stress
GO_0046296	Biological process	glycolate catabolic process
GO_0001561	Biological process	fatty acid alpha-oxidation
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005829	Cellular component	cytosol
GO_0005782	Cellular component	peroxisomal matrix
GO_0047969	Molecular function	glyoxylate oxidase activity
GO_0010181	Molecular function	FMN binding
GO_0003973	Molecular function	(S)-2-hydroxy-acid oxidase activity

Gene name	HAO1
Protein name	Hydroxyacid oxidase (Glycolate oxidase) 1, isoform CRA_a (cDNA FLJ78493, highly similar to Homo sapiens hydroxyacid oxidase (glycolate oxidase) 1 (HAO1), mRNA) (cDNA, FLJ94465, Homo sapiens hydroxyacid oxidase (glycolate oxidase) 1 (HAO1),mRNA) 2-Hydroxyacid oxidase 1 (HAOX1) (EC 1.1.3.15) (Glycolate oxidase) (GO) (GOX) (Glyoxylate oxidase) (EC 1.2.3.5) Alternative protein HAO1
Synonyms	GOX1 hCG_39600
Description	FUNCTION: Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate . The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones . Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency . Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 . Is not active on L-lactate and 2-hydroxybutanoate . .
Accessions	ENST00000378789.4 L8E8S6 Q9UJM8 A8K058

HAO1 report