HABP2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HABP2 at tissue level.

III. Associated gene sets

GO_0007155Biological processcell adhesion
GO_0006508Biological processproteolysis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0008233Molecular functionpeptidase activity
GO_0005509Molecular functioncalcium ion binding
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0005539Molecular functionglycosaminoglycan binding

IV. Literature review

[source]
Gene nameHABP2
Protein nameHyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
Brevican core protein
SynonymsHGFAL
PHBP
DescriptionFUNCTION: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII . May function as a tumor suppressor negatively regulating cell proliferation and cell migration . .

AccessionsENST00000351270.4 [Q14520-1]
Q14520
Q8IWX2
ENST00000542051.5 [Q14520-2]