H3Y1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H3Y1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H3Y1 at tissue level.

III. Associated gene sets

GO_0005654Cellular componentnucleoplasm
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031492Molecular functionnucleosomal DNA binding
GO_0030527Molecular functionstructural constituent of chromatin

IV. Literature review

[source]
Gene nameH3Y1
Protein nameHistone H3.Y (Histone H3.Y1)
Synonyms
DescriptionFUNCTION: Primate-specific variant histone H3, which constitutes a core component of nucleosomes . Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flexible DNA ends, suggesting that they form relaxed chromatin that allows transcription factor access . Histone H1 binds less efficiently to histone H3.Y-containing nucleosomes . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable). .

AccessionsENST00000598383.3
P0DPK2