H1-8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of H1-8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of H1-8 at tissue level.

III. Associated gene sets

GO_0051321Biological processmeiotic cell cycle
GO_0040029Biological processepigenetic regulation of gene expression
GO_0045910Biological processnegative regulation of DNA recombination
GO_0006334Biological processnucleosome assembly
GO_0030261Biological processchromosome condensation
GO_0005730Cellular componentnucleolus
GO_0070062Cellular componentextracellular exosome
GO_0000786Cellular componentnucleosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0030527Molecular functionstructural constituent of chromatin
GO_0031492Molecular functionnucleosomal DNA binding

IV. Literature review

[source]
Gene nameH1-8
Protein nameHistone H1.8 (Histone H1oo) (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) (osH1)
SynonymsH1OO
H1FOO
OSH1
DescriptionFUNCTION: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). .

AccessionsENST00000324382.7 [Q8IZA3-1]
ENST00000503977.1 [Q8IZA3-2]
Q8IZA3