GRPEL2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GRPEL2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GRPEL2 at tissue level.

III. Associated gene sets

GO_0006457Biological processprotein folding
GO_0030150Biological processprotein import into mitochondrial matrix
GO_0006886Biological processintracellular protein transport
GO_0001405Cellular componentPAM complex, Tim23 associated import motor
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005744Cellular componentTIM23 mitochondrial import inner membrane translocase complex
GO_0042803Molecular functionprotein homodimerization activity
GO_0051082Molecular functionunfolded protein binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0000774Molecular functionadenyl-nucleotide exchange factor activity

IV. Literature review

[source]
Gene nameGRPEL2
Protein nameGrpE protein homolog 2, mitochondrial (Mt-GrpE#2)
GrpE like 2, mitochondrial
Synonyms
DescriptionFUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). .

AccessionsD6RGI6
Q8TAA5
ENST00000416916.2 [Q8TAA5-2]
ENST00000329271.8 [Q8TAA5-1]
ENST00000513661.5