GRK1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GRK1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GRK1 at tissue level.

III. Associated gene sets

GO_0009966Biological processregulation of signal transduction
GO_0007601Biological processvisual perception
GO_0016056Biological processG protein-coupled opsin signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0046777Biological processprotein autophosphorylation
GO_0022400Biological processregulation of opsin-mediated signaling pathway
GO_0097381Cellular componentphotoreceptor disc membrane
GO_0005737Cellular componentcytoplasm
GO_0050254Molecular functionrhodopsin kinase activity
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene nameGRK1
Protein nameG protein-coupled receptor kinase (EC 2.7.11.-)
G protein-coupled receptor kinase 1
Rhodopsin kinase GRK1 (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1)
G protein-coupled receptor kinase 1b
SynonymsRHOK
DescriptionFUNCTION: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade . This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). .

AccessionsA0A0J9YXB6
B9EIS4
ENST00000335678.7
O95098
Q71VB6
Q15835
ENST00000672946.1
ENST00000631997.1