I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| enterocyte | 4 studies | 18% ± 3% | |
| hepatocyte | 3 studies | 28% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| enterocyte | 4 studies | 18% ± 3% | |
| hepatocyte | 3 studies | 28% ± 5% |
Insufficient scRNA-seq data for expression of GPT at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 8616.51 | 226 / 226 | 99% | 77.53 | 400 / 406 |
| kidney | 96% | 1094.40 | 85 / 89 | 86% | 13.16 | 771 / 901 |
| pancreas | 98% | 635.67 | 323 / 328 | 75% | 6.86 | 134 / 178 |
| brain | 80% | 381.40 | 2124 / 2642 | 89% | 6.73 | 628 / 705 |
| stomach | 77% | 1106.48 | 277 / 359 | 72% | 6.98 | 206 / 286 |
| breast | 87% | 1231.97 | 398 / 459 | 59% | 5.73 | 664 / 1118 |
| intestine | 55% | 1943.43 | 530 / 966 | 78% | 9.67 | 412 / 527 |
| prostate | 73% | 311.52 | 180 / 245 | 58% | 2.86 | 290 / 502 |
| ovary | 35% | 118.42 | 63 / 180 | 88% | 11.12 | 378 / 430 |
| adrenal gland | 69% | 241.55 | 177 / 258 | 40% | 1.88 | 93 / 230 |
| thymus | 51% | 158.80 | 333 / 653 | 53% | 2.92 | 318 / 605 |
| ureter | 0% | 0 | 0 / 0 | 100% | 38.07 | 1 / 1 |
| muscle | 99% | 2112.86 | 796 / 803 | 0% | 0 | 0 / 0 |
| heart | 95% | 1550.55 | 820 / 861 | 0% | 0 | 0 / 0 |
| adipose | 93% | 1824.90 | 1122 / 1204 | 0% | 0 | 0 / 0 |
| skin | 72% | 979.23 | 1300 / 1809 | 17% | 0.76 | 80 / 472 |
| esophagus | 24% | 96.88 | 349 / 1445 | 48% | 4.44 | 88 / 183 |
| bladder | 14% | 36.48 | 3 / 21 | 47% | 3.43 | 237 / 504 |
| uterus | 14% | 40.39 | 24 / 170 | 45% | 3.39 | 205 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 49% | 2.41 | 22 / 45 |
| lung | 5% | 12.37 | 28 / 578 | 42% | 2.84 | 487 / 1155 |
| eye | 0% | 0 | 0 / 0 | 29% | 1.07 | 23 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.81 | 5 / 29 |
| blood vessel | 13% | 95.26 | 179 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 3% | 13.40 | 8 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 3.94 | 9 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045722 | Biological process | positive regulation of gluconeogenesis |
| GO_0042853 | Biological process | L-alanine catabolic process |
| GO_0009058 | Biological process | biosynthetic process |
| GO_0032869 | Biological process | cellular response to insulin stimulus |
| GO_0042594 | Biological process | response to starvation |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0004021 | Molecular function | L-alanine:2-oxoglutarate aminotransferase activity |
| GO_0030170 | Molecular function | pyridoxal phosphate binding |
| Gene name | GPT |
| Protein name | Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1) |
| Synonyms | AAT1 GPT1 |
| Description | FUNCTION: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). . |
| Accessions | P24298 ENST00000528431.5 ENST00000394955.3 |
