GPR84 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR84 at tissue level.

III. Associated gene sets

GO_0007218Biological processneuropeptide signaling pathway
GO_0008150Biological processbiological_process
GO_0070821Cellular componenttertiary granule membrane
GO_0043235Cellular componentreceptor complex
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0001604Molecular functionurotensin II receptor activity

IV. Literature review

[source]
Gene nameGPR84
Protein nameG-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33)
SynonymsEX33
DescriptionFUNCTION: G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists . In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (By similarity). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (By similarity). Plays also an important role in inflammation by modulating neutrophil functions (By similarity). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (By similarity). To regulate ROS, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils . .

AccessionsQ9NQS5
ENST00000267015.4
ENST00000551809.1