Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte precursor cell | 14 studies | 33% ± 15% | |
macrophage | 10 studies | 30% ± 16% | |
glutamatergic neuron | 10 studies | 42% ± 24% | |
GABAergic neuron | 9 studies | 43% ± 24% | |
neuron | 6 studies | 30% ± 15% | |
astrocyte | 5 studies | 23% ± 6% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
glial cell | 4 studies | 45% ± 20% | |
retinal cone cell | 4 studies | 37% ± 12% | |
microglial cell | 4 studies | 24% ± 9% | |
melanocyte | 4 studies | 35% ± 12% | |
interneuron | 4 studies | 50% ± 19% | |
retinal ganglion cell | 3 studies | 33% ± 13% | |
monocyte | 3 studies | 19% ± 3% | |
Schwann cell | 3 studies | 56% ± 19% | |
oligodendrocyte | 3 studies | 23% ± 6% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 10 studies | 36% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 3154.64 | 2635 / 2642 | 100% | 21.57 | 703 / 705 |
prostate | 100% | 1519.36 | 244 / 245 | 99% | 9.05 | 499 / 502 |
adrenal gland | 98% | 1171.07 | 253 / 258 | 91% | 22.38 | 210 / 230 |
esophagus | 97% | 2382.17 | 1398 / 1445 | 91% | 8.80 | 167 / 183 |
lung | 95% | 806.31 | 551 / 578 | 92% | 6.23 | 1062 / 1155 |
kidney | 100% | 1391.76 | 89 / 89 | 85% | 8.08 | 766 / 901 |
thymus | 98% | 982.61 | 643 / 653 | 85% | 4.51 | 514 / 605 |
liver | 96% | 795.88 | 218 / 226 | 86% | 4.83 | 350 / 406 |
pancreas | 100% | 1543.00 | 327 / 328 | 83% | 4.02 | 147 / 178 |
skin | 89% | 1335.01 | 1605 / 1809 | 88% | 19.69 | 417 / 472 |
breast | 90% | 629.85 | 415 / 459 | 87% | 4.83 | 968 / 1118 |
stomach | 100% | 5350.56 | 359 / 359 | 75% | 7.11 | 215 / 286 |
ovary | 91% | 628.20 | 163 / 180 | 73% | 3.32 | 315 / 430 |
intestine | 99% | 2539.43 | 952 / 966 | 62% | 4.55 | 328 / 527 |
uterus | 95% | 682.09 | 162 / 170 | 63% | 3.31 | 289 / 459 |
bladder | 100% | 1272.52 | 21 / 21 | 55% | 3.19 | 277 / 504 |
spleen | 100% | 1202.34 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.86 | 1 / 1 |
blood vessel | 99% | 1161.92 | 1323 / 1335 | 0% | 0 | 0 / 0 |
muscle | 97% | 852.39 | 776 / 803 | 0% | 0 | 0 / 0 |
adipose | 95% | 812.13 | 1148 / 1204 | 0% | 0 | 0 / 0 |
heart | 92% | 1226.29 | 791 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 87% | 1211.39 | 811 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 82% | 3.76 | 37 / 45 |
lymph node | 0% | 0 | 0 / 0 | 72% | 3.98 | 21 / 29 |
eye | 0% | 0 | 0 / 0 | 18% | 0.49 | 14 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0050890 | Biological process | cognition |
GO_0035556 | Biological process | intracellular signal transduction |
GO_1904263 | Biological process | positive regulation of TORC1 signaling |
GO_0030514 | Biological process | negative regulation of BMP signaling pathway |
GO_0071397 | Biological process | cellular response to cholesterol |
GO_0034198 | Biological process | cellular response to amino acid starvation |
GO_0055085 | Biological process | transmembrane transport |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0015485 | Molecular function | cholesterol binding |
GO_0003674 | Molecular function | molecular_function |
Gene name | GPR155 |
Protein name | Lysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22) G protein-coupled receptor 155 GPR155 protein |
Synonyms | PGR22 |
Description | FUNCTION: Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway . Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling . Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition . . |
Accessions | Q7Z3F1 ENST00000392551.6 Q49AJ5 ENST00000295500.8 ENST00000614352.4 A0A087WXK4 ENST00000392552.7 |