GPR155 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050890Biological processcognition
GO_0035556Biological processintracellular signal transduction
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0071397Biological processcellular response to cholesterol
GO_0034198Biological processcellular response to amino acid starvation
GO_0055085Biological processtransmembrane transport
GO_0070062Cellular componentextracellular exosome
GO_0005765Cellular componentlysosomal membrane
GO_0015485Molecular functioncholesterol binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameGPR155
Protein nameLysosomal cholesterol signaling protein (LYCHOS) (G-protein coupled receptor PGR22)
G protein-coupled receptor 155
GPR155 protein
SynonymsPGR22
DescriptionFUNCTION: Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway . Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling . Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition . .

AccessionsQ7Z3F1
ENST00000392551.6
Q49AJ5
ENST00000295500.8
ENST00000614352.4
A0A087WXK4
ENST00000392552.7