GPAT2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPAT2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPAT2 at tissue level.

III. Associated gene sets

GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0034587Biological processpiRNA processing
GO_0019432Biological processtriglyceride biosynthetic process
GO_0008654Biological processphospholipid biosynthetic process
GO_0006072Biological processglycerol-3-phosphate metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0016024Biological processCDP-diacylglycerol biosynthetic process
GO_0005741Cellular componentmitochondrial outer membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0005739Cellular componentmitochondrion
GO_0004366Molecular functionglycerol-3-phosphate O-acyltransferase activity
GO_0003841Molecular function1-acylglycerol-3-phosphate O-acyltransferase activity
GO_0102420Molecular functionsn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity

IV. Literature review

[source]
Gene nameGPAT2
Protein nameGlycerol-3-phosphate acyltransferase 2, mitochondrial
Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT-2) (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase GPAT2) (EC 2.3.1.51) (xGPAT1)
Synonyms
DescriptionFUNCTION: Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. .

AccessionsENST00000687910.1 [Q6NUI2-3]
Q6NUI2
ENST00000453542.5
C9JYV5
ENST00000359548.8 [Q6NUI2-1]
ENST00000691940.1 [Q6NUI2-1]
ENST00000439254.1
ENST00000434632.6 [Q6NUI2-4]
E9PE95