GJA3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GJA3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GJA3 at tissue level.

III. Associated gene sets

GO_0007267Biological processcell-cell signaling
GO_0007601Biological processvisual perception
GO_1990349Biological processgap junction-mediated intercellular transport
GO_0055085Biological processtransmembrane transport
GO_0005922Cellular componentconnexin complex
GO_0005886Cellular componentplasma membrane
GO_0005243Molecular functiongap junction channel activity
GO_0055077Molecular functiongap junction hemi-channel activity

IV. Literature review

[source]
Gene nameGJA3
Protein nameGap junction protein
Gap junction alpha-3 protein
Gap junction alpha-3 protein (Connexin-46) (Cx46)
SynonymshCG_20494
CXNJ1
DescriptionFUNCTION: Structural component of lens fiber gap junctions . Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells (By similarity). They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore . .

FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. .

AccessionsA0A1B1PFX4
A0A1B3B2J9
A0A140CTW6
A0A654IE12
A0A1B1PFX6
A0A140CTW7
A0A140CTW5
ENST00000241125.4
A0A140CTW8
Q9Y6H8
A0A1B3B2J5