GID4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GID4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GID4 at tissue level.

III. Associated gene sets

GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000151Cellular componentubiquitin ligase complex
GO_0061630Molecular functionubiquitin protein ligase activity

IV. Literature review

[source]
Gene nameGID4
Protein nameGID complex subunit 4 homolog
Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog)
SynonymsVID24
C17orf39
DescriptionFUNCTION: Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (Probable) . Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp . Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind peptides with an acetylated N-terminal Pro residue . .

AccessionsK7ELH7
ENST00000376345.3
ENST00000481836.2
Q8IVV7
ENST00000268719.9
K4DI96
ENST00000459843.5
K7ENE2