I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 6 studies | 70% ± 25% | |
| pancreatic A cell | 4 studies | 89% ± 7% | |
| cholangiocyte | 3 studies | 62% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 6 studies | 70% ± 25% | |
| pancreatic A cell | 4 studies | 89% ± 7% | |
| cholangiocyte | 3 studies | 62% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 95010.67 | 226 / 226 | 97% | 3095.65 | 395 / 406 |
| pancreas | 100% | 1357.88 | 328 / 328 | 25% | 178.08 | 45 / 178 |
| stomach | 80% | 736.08 | 287 / 359 | 3% | 20.77 | 10 / 286 |
| kidney | 48% | 53.75 | 43 / 89 | 3% | 19.60 | 30 / 901 |
| peripheral blood | 28% | 141.47 | 262 / 929 | 0% | 0 | 0 / 0 |
| esophagus | 13% | 8.77 | 182 / 1445 | 2% | 31.33 | 3 / 183 |
| lung | 12% | 6.12 | 69 / 578 | 1% | 2.63 | 10 / 1155 |
| spleen | 12% | 215.98 | 30 / 241 | 0% | 0 | 0 / 0 |
| intestine | 9% | 6.98 | 83 / 966 | 3% | 15.74 | 15 / 527 |
| uterus | 10% | 3.12 | 17 / 170 | 0% | 0 | 0 / 459 |
| adrenal gland | 9% | 5.18 | 24 / 258 | 0% | 0 | 0 / 230 |
| ovary | 8% | 2.15 | 15 / 180 | 0% | 0 | 0 / 430 |
| prostate | 7% | 1.91 | 18 / 245 | 0% | 1.26 | 2 / 502 |
| breast | 7% | 5.55 | 34 / 459 | 0% | 0.51 | 1 / 1118 |
| adipose | 7% | 23.96 | 88 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 6% | 3.07 | 41 / 653 | 0% | 0 | 0 / 605 |
| blood vessel | 6% | 3.02 | 78 / 1335 | 0% | 0 | 0 / 0 |
| heart | 6% | 5.79 | 48 / 861 | 0% | 0 | 0 / 0 |
| skin | 4% | 3.85 | 79 / 1809 | 0% | 0 | 0 / 472 |
| muscle | 3% | 1.46 | 25 / 803 | 0% | 0 | 0 / 0 |
| brain | 3% | 1.26 | 72 / 2642 | 0% | 0 | 0 / 705 |
| bladder | 0% | 0 | 0 / 21 | 0% | 4.16 | 1 / 504 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006810 | Biological process | transport |
| GO_0035461 | Biological process | vitamin transmembrane transport |
| GO_0051180 | Biological process | vitamin transport |
| GO_0042359 | Biological process | vitamin D metabolic process |
| GO_0005615 | Cellular component | extracellular space |
| GO_0072562 | Cellular component | blood microparticle |
| GO_0043202 | Cellular component | lysosomal lumen |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005499 | Molecular function | vitamin D binding |
| GO_1902118 | Molecular function | calcidiol binding |
| GO_0003779 | Molecular function | actin binding |
| GO_0090482 | Molecular function | vitamin transmembrane transporter activity |
| Gene name | GC |
| Protein name | Vitamin D binding protein Vitamin D-binding protein (Gc-globulin) (Group-specific component) Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf) |
| Synonyms | HEL-S-51 |
| Description | FUNCTION: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. . FUNCTION: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. . FUNCTION: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. . FUNCTION: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. . FUNCTION: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. . |
| Accessions | ENST00000273951.13 [P02774-1] ENST00000513476.5 V9HWI6 P02774 ENST00000509740.5 ENST00000506245.1 D6RBJ7 D6RF35 D6RF20 ENST00000504199.5 [P02774-3] A0A0D3S2Q0 |
