GALNT12 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GALNT12 at tissue level.

III. Associated gene sets

GO_0016266Biological processO-glycan processing
GO_0006493Biological processprotein O-linked glycosylation
GO_0000139Cellular componentGolgi membrane
GO_0005794Cellular componentGolgi apparatus
GO_0004653Molecular functionpolypeptide N-acetylgalactosaminyltransferase activity
GO_0030246Molecular functioncarbohydrate binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameGALNT12
Protein namePolypeptide N-acetylgalactosaminyltransferase 12
Alternative protein GALNT12
Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)
Synonyms
DescriptionFUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.

AccessionsL8EB63
ENST00000375011.4 [Q8IXK2-1]
A0A087WT76
ENST00000610463.1
Q68VJ1
Q8IXK2