GALE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033499Biological processgalactose catabolic process via UDP-galactose
GO_0019388Biological processgalactose catabolic process
GO_0005829Cellular componentcytosol
GO_0003974Molecular functionUDP-N-acetylglucosamine 4-epimerase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0003978Molecular functionUDP-glucose 4-epimerase activity

IV. Literature review

[source]
Gene nameGALE
Protein nameUDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)
UDP-glucose 4-epimerase (EC 5.1.3.2)
Synonyms
DescriptionFUNCTION: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. .

AccessionsQ5QPP4
ENST00000418277.5
Q5QPP9
ENST00000456977.5
ENST00000425913.5
ENST00000617979.5 [Q14376-1]
ENST00000445705.1
Q14376
Q5QPP1
Q5QPP3
ENST00000374497.7 [Q14376-1]
ENST00000429356.5