FUT6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FUT6 at tissue level.

III. Associated gene sets

GO_0007309Biological processoocyte axis specification
GO_0006672Biological processceramide metabolic process
GO_0006487Biological processprotein N-linked glycosylation
GO_0009312Biological processoligosaccharide biosynthetic process
GO_0006688Biological processglycosphingolipid biosynthetic process
GO_0006493Biological processprotein O-linked glycosylation
GO_0042355Biological processL-fucose catabolic process
GO_0036071Biological processN-glycan fucosylation
GO_0006486Biological processprotein glycosylation
GO_0034709Cellular componentmethylosome
GO_0000139Cellular componentGolgi membrane
GO_0070062Cellular componentextracellular exosome
GO_0032580Cellular componentGolgi cisterna membrane
GO_0005576Cellular componentextracellular region
GO_0005794Cellular componentGolgi apparatus
GO_0046920Molecular functionalpha-(1->3)-fucosyltransferase activity
GO_0008417Molecular functionfucosyltransferase activity
GO_0017083Molecular function4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity

IV. Literature review

[source]
Gene nameFUT6
Protein name4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (EC 2.4.1.152) (Fucosyltransferase 6) (Fucosyltransferase VI) (Fuc-TVI) (FucT-VI) (Galactoside 3-L-fucosyltransferase)
Fucosyltransferase 6
Fucosyltransferase (EC 2.4.1.-)
SynonymsFCT3A
DescriptionFUNCTION: [Isoform 1]: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants . Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants . Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X . Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates . .; FUNCTION: [Isoform 2]: Does not have alpha(1,3)-fucosyltransferase activity. .

AccessionsENST00000286955.5 [P51993-1]
ENST00000524754.1 [P51993-1]
ENST00000532464.5
E9PP56
P51993
ENST00000318336.10 [P51993-1]
E9PJB4
E9PS22
ENST00000531199.1
ENST00000531085.5
ENST00000528505.1
E9PJ18
ENST00000592563.1 [P51993-2]
Q6P7E6
ENST00000527106.5 [P51993-1]