FREY1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FREY1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FREY1 at tissue level.

III. Associated gene sets

GO_0035437Biological processmaintenance of protein localization in endoplasmic reticulum
GO_0035036Biological processsperm-egg recognition
GO_0007342Biological processfusion of sperm to egg plasma membrane involved in single fertilization
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030674Molecular functionprotein-macromolecule adaptor activity

IV. Literature review

[source]
Gene nameFREY1
Protein nameProtein Frey 1 (Frey regulator of sperm-oocyte fusion 1) (FREY1)
SynonymsFREY
C11orf94
DescriptionFUNCTION: Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome. Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP. .

AccessionsENST00000449465.2
C9JXX5