FOLH1 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte	17 studies	46% ± 19%	Explore
epithelial cell	3 studies	24% ± 10%	Explore

Name	Number of supported studies	Average coverage
brain	5 studies	30% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	96%	6312.00	236 / 245	100%	382.87	501 / 502
brain	95%	1496.84	2509 / 2642	68%	8.04	480 / 705
liver	96%	661.40	216 / 226	63%	5.54	254 / 406
kidney	91%	391.76	81 / 89	60%	12.31	543 / 901
lung	66%	136.03	381 / 578	34%	3.32	393 / 1155
breast	58%	195.42	266 / 459	32%	2.76	363 / 1118
spleen	90%	231.49	217 / 241	0%	0	0 / 0
skin	33%	56.40	605 / 1809	27%	4.01	127 / 472
esophagus	31%	51.35	444 / 1445	27%	2.65	50 / 183
ovary	21%	34.68	38 / 180	33%	2.26	140 / 430
thymus	24%	32.59	156 / 653	25%	1.33	149 / 605
bladder	29%	71.57	6 / 21	11%	0.97	54 / 504
adrenal gland	2%	2.44	5 / 258	37%	5.54	84 / 230
intestine	27%	80.37	260 / 966	8%	0.71	42 / 527
uterus	13%	21.41	22 / 170	22%	1.70	99 / 459
adipose	29%	56.38	355 / 1204	0%	0	0 / 0
stomach	9%	12.65	32 / 359	10%	0.90	30 / 286
pancreas	0%	0	0 / 328	19%	3.31	33 / 178
tonsil	0%	0	0 / 0	18%	1.22	8 / 45
blood vessel	10%	25.23	137 / 1335	0%	0	0 / 0
heart	7%	11.47	62 / 861	0%	0	0 / 0
muscle	0%	0.16	1 / 803	0%	0	0 / 0
peripheral blood	0%	0.13	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0035609	Biological process	C-terminal protein deglutamylation
GO_0006760	Biological process	folic acid-containing compound metabolic process
GO_0006508	Biological process	proteolysis
GO_0009986	Cellular component	cell surface
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0008233	Molecular function	peptidase activity
GO_1904492	Molecular function	Ac-Asp-Glu binding
GO_0004180	Molecular function	carboxypeptidase activity
GO_0016805	Molecular function	dipeptidase activity
GO_1904493	Molecular function	tetrahydrofolyl-poly(glutamate) polymer binding
GO_0046872	Molecular function	metal ion binding
GO_0004181	Molecular function	metallocarboxypeptidase activity

Gene name	FOLH1
Protein name	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase) Folate hydrolase 1 FOLH1 protein
Synonyms	FOLH PSMA PSM NAALAD1 GIG27
Description	FUNCTION: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.; FUNCTION: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Accessions	ENST00000340334.11 [Q04609-7] E9PI29 E9PLV0 Q04609 ENST00000256999.7 [Q04609-1] ENST00000529648.1 ENST00000533034.1 [Q04609-9] ENST00000529117.1 Q2VPJ0 E9PKM3 E9PMK6 ENST00000525826.5 ENST00000533510.5 ENST00000356696.7 [Q04609-8]

FOLH1 report