FMO2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FMO2 at tissue level.

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0070995Biological processNADPH oxidation
GO_0072592Biological processoxygen metabolic process
GO_0006739Biological processNADP metabolic process
GO_0009404Biological processtoxin metabolic process
GO_0006805Biological processxenobiotic metabolic process
GO_0006082Biological processorganic acid metabolic process
GO_0046322Biological processnegative regulation of fatty acid oxidation
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0047822Molecular functionhypotaurine dehydrogenase activity
GO_0050661Molecular functionNADP binding
GO_0004499Molecular functionN,N-dimethylaniline monooxygenase activity
GO_0050660Molecular functionflavin adenine dinucleotide binding

IV. Literature review

[source]
Gene nameFMO2
Protein nameDimethylaniline oxidase 2 (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2)
Flavin-containing monooxygenase 2 (EC 1.14.13.-) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)
Synonyms
DescriptionFUNCTION: Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation . Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid . In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate . Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton . .

AccessionsENST00000529935.5
Q99518
ENST00000483192.2
A0A0D9SG76
A0A0D9SFZ0
ENST00000209929.10