FLVCR2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FLVCR2 at tissue level.

III. Associated gene sets

GO_0097037Biological processheme export
GO_0055085Biological processtransmembrane transport
GO_0031966Cellular componentmitochondrial membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0015232Molecular functionheme transmembrane transporter activity
GO_0020037Molecular functionheme binding

IV. Literature review

[source]
Gene nameFLVCR2
Protein nameHeme transporter FLVCR2 (Calcium-chelate transporter) (CCT) (Feline leukemia virus subgroup C receptor-related protein 2)
FLVCR heme transporter 2
SynonymsC14orf58
DescriptionFUNCTION: Putative heme b importer/sensor involved in heme homeostasis in response to the metabolic state of the cell and to diet. May act as a sensor of cytosolic and/or mitochondrial heme levels to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis. At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis. Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis. Alternatively, in coordination with ATP2A2 may mediate calcium transport and signaling in response to heme. .

AccessionsG3V5P5
ENST00000553341.5
ENST00000555027.1
ENST00000553587.5
G3V5Q8
Q9UPI3
ENST00000556856.1
G3V5Y3
G3V391
G3V4G2
ENST00000539311.5 [Q9UPI3-2]
ENST00000554580.5
ENST00000238667.9 [Q9UPI3-1]
G3V458
ENST00000555058.5